Synthesis of the Tripeptides Tyr-Thr-Lys Phosphorylated with Isopropyl Methyl- and (Deuteromethyl)phosphonochloridates as Reference Standards for the Analysis of Biomedical Samples
- 作者: Rodin I.1, Baygildiev T.1, Krylov V.2, Osipov V.3, Krylov I.2, Yashkir V.2, Rybalchenko I.2
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隶属关系:
- Chemical Department
- 27 Research Center
- Farmsintez ZAO
- 期: 卷 89, 编号 10 (2019)
- 页面: 2103-2107
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223124
- DOI: https://doi.org/10.1134/S1070363219100189
- ID: 223124
如何引用文章
详细
A procedure for the phosphorylation of the tripeptide Tyr-Thr-Lys with isopropyl methyl- or (deuteromethyl)phosphonochloridate is developed. The phosphorylated tripeptides are intended for use as reference standards in the analysis of blood samples of people suspected to have been exposed to acetylcholinesterase inhibitors. Conditions of hromatographic separation and purification of the synthesized compounds are determined and optimized, which ensures the preparation of high-purity phosphorylated tripeptides.
作者简介
I. Rodin
Chemical Department
编辑信件的主要联系方式.
Email: igorrodin@yandex.ru
俄罗斯联邦, Moscow, 119991
T. Baygildiev
Chemical Department
Email: igorrodin@yandex.ru
俄罗斯联邦, Moscow, 119991
V. Krylov
27 Research Center
Email: igorrodin@yandex.ru
俄罗斯联邦, Moscow, 105005
V. Osipov
Farmsintez ZAO
Email: igorrodin@yandex.ru
俄罗斯联邦, Moscow, 111024
I. Krylov
27 Research Center
Email: igorrodin@yandex.ru
俄罗斯联邦, Moscow, 105005
V. Yashkir
27 Research Center
Email: igorrodin@yandex.ru
俄罗斯联邦, Moscow, 105005
I. Rybalchenko
27 Research Center
Email: igorrodin@yandex.ru
俄罗斯联邦, Moscow, 105005
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