Synthesis of the Tripeptides Tyr-Thr-Lys Phosphorylated with Isopropyl Methyl- and (Deuteromethyl)phosphonochloridates as Reference Standards for the Analysis of Biomedical Samples
- Авторы: Rodin I.1, Baygildiev T.1, Krylov V.2, Osipov V.3, Krylov I.2, Yashkir V.2, Rybalchenko I.2
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Учреждения:
- Chemical Department
- 27 Research Center
- Farmsintez ZAO
- Выпуск: Том 89, № 10 (2019)
- Страницы: 2103-2107
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223124
- DOI: https://doi.org/10.1134/S1070363219100189
- ID: 223124
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Аннотация
A procedure for the phosphorylation of the tripeptide Tyr-Thr-Lys with isopropyl methyl- or (deuteromethyl)phosphonochloridate is developed. The phosphorylated tripeptides are intended for use as reference standards in the analysis of blood samples of people suspected to have been exposed to acetylcholinesterase inhibitors. Conditions of hromatographic separation and purification of the synthesized compounds are determined and optimized, which ensures the preparation of high-purity phosphorylated tripeptides.
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Об авторах
I. Rodin
Chemical Department
Автор, ответственный за переписку.
Email: igorrodin@yandex.ru
Россия, Moscow, 119991
T. Baygildiev
Chemical Department
Email: igorrodin@yandex.ru
Россия, Moscow, 119991
V. Krylov
27 Research Center
Email: igorrodin@yandex.ru
Россия, Moscow, 105005
V. Osipov
Farmsintez ZAO
Email: igorrodin@yandex.ru
Россия, Moscow, 111024
I. Krylov
27 Research Center
Email: igorrodin@yandex.ru
Россия, Moscow, 105005
V. Yashkir
27 Research Center
Email: igorrodin@yandex.ru
Россия, Moscow, 105005
I. Rybalchenko
27 Research Center
Email: igorrodin@yandex.ru
Россия, Moscow, 105005
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