Synthesis of the Tripeptides Tyr-Thr-Lys Phosphorylated with Isopropyl Methyl- and (Deuteromethyl)phosphonochloridates as Reference Standards for the Analysis of Biomedical Samples
- Autores: Rodin I.1, Baygildiev T.1, Krylov V.2, Osipov V.3, Krylov I.2, Yashkir V.2, Rybalchenko I.2
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Afiliações:
- Chemical Department
- 27 Research Center
- Farmsintez ZAO
- Edição: Volume 89, Nº 10 (2019)
- Páginas: 2103-2107
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223124
- DOI: https://doi.org/10.1134/S1070363219100189
- ID: 223124
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Resumo
A procedure for the phosphorylation of the tripeptide Tyr-Thr-Lys with isopropyl methyl- or (deuteromethyl)phosphonochloridate is developed. The phosphorylated tripeptides are intended for use as reference standards in the analysis of blood samples of people suspected to have been exposed to acetylcholinesterase inhibitors. Conditions of hromatographic separation and purification of the synthesized compounds are determined and optimized, which ensures the preparation of high-purity phosphorylated tripeptides.
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Sobre autores
I. Rodin
Chemical Department
Autor responsável pela correspondência
Email: igorrodin@yandex.ru
Rússia, Moscow, 119991
T. Baygildiev
Chemical Department
Email: igorrodin@yandex.ru
Rússia, Moscow, 119991
V. Krylov
27 Research Center
Email: igorrodin@yandex.ru
Rússia, Moscow, 105005
V. Osipov
Farmsintez ZAO
Email: igorrodin@yandex.ru
Rússia, Moscow, 111024
I. Krylov
27 Research Center
Email: igorrodin@yandex.ru
Rússia, Moscow, 105005
V. Yashkir
27 Research Center
Email: igorrodin@yandex.ru
Rússia, Moscow, 105005
I. Rybalchenko
27 Research Center
Email: igorrodin@yandex.ru
Rússia, Moscow, 105005
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