Synthesis of the Tripeptides Tyr-Thr-Lys Phosphorylated with Isopropyl Methyl- and (Deuteromethyl)phosphonochloridates as Reference Standards for the Analysis of Biomedical Samples
- Авторлар: Rodin I.1, Baygildiev T.1, Krylov V.2, Osipov V.3, Krylov I.2, Yashkir V.2, Rybalchenko I.2
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Мекемелер:
- Chemical Department
- 27 Research Center
- Farmsintez ZAO
- Шығарылым: Том 89, № 10 (2019)
- Беттер: 2103-2107
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223124
- DOI: https://doi.org/10.1134/S1070363219100189
- ID: 223124
Дәйексөз келтіру
Аннотация
A procedure for the phosphorylation of the tripeptide Tyr-Thr-Lys with isopropyl methyl- or (deuteromethyl)phosphonochloridate is developed. The phosphorylated tripeptides are intended for use as reference standards in the analysis of blood samples of people suspected to have been exposed to acetylcholinesterase inhibitors. Conditions of hromatographic separation and purification of the synthesized compounds are determined and optimized, which ensures the preparation of high-purity phosphorylated tripeptides.
Негізгі сөздер
Авторлар туралы
I. Rodin
Chemical Department
Хат алмасуға жауапты Автор.
Email: igorrodin@yandex.ru
Ресей, Moscow, 119991
T. Baygildiev
Chemical Department
Email: igorrodin@yandex.ru
Ресей, Moscow, 119991
V. Krylov
27 Research Center
Email: igorrodin@yandex.ru
Ресей, Moscow, 105005
V. Osipov
Farmsintez ZAO
Email: igorrodin@yandex.ru
Ресей, Moscow, 111024
I. Krylov
27 Research Center
Email: igorrodin@yandex.ru
Ресей, Moscow, 105005
V. Yashkir
27 Research Center
Email: igorrodin@yandex.ru
Ресей, Moscow, 105005
I. Rybalchenko
27 Research Center
Email: igorrodin@yandex.ru
Ресей, Moscow, 105005
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