Synthesis and Cytotoxicity of 1,4-Naphthoquinone Oxime Derivatives
- Авторлар: Zhang Q.1, Dong J.1, Meng Q.1, Huang G.1, Li S.1
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Мекемелер:
- School of Pharmacy
- Шығарылым: Том 88, № 11 (2018)
- Беттер: 2388-2393
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222547
- DOI: https://doi.org/10.1134/S1070363218110221
- ID: 222547
Дәйексөз келтіру
Аннотация
A series of hydroxylated 1,4-naphthoquinone oximes were designed and synthesized. The in vitro cytotoxicity of these compounds was evaluated against five human cancer cell lines and human skin fibroblast cell line. Among them, compounds (1E,4E)-6-{1-[(5-Hydroxypentyl)oxy]-2,2-dimethylbut-3-en-1-yl}-5,8- dimethoxynaphthalene-1,4-dione dioxime and (1E,4E)-6-{1-[(6-Hydroxyhexyl)oxy]-2,2-dimethylbut-3-en-1-yl}-5,8-dimethoxynaphthalene-1,4-dione dioxime displayed higher cytotoxicity in three cancer cell lines than the positive drug 5-fluorouracil
Негізгі сөздер
Авторлар туралы
Q. Zhang
School of Pharmacy
Хат алмасуға жауапты Автор.
Email: lianyi1126@sjtu.edu.cn
ҚХР, 800 Dongchuan Road, Shanghai, 200240
J. Dong
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
ҚХР, 800 Dongchuan Road, Shanghai, 200240
Q. Meng
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
ҚХР, 800 Dongchuan Road, Shanghai, 200240
G. Huang
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
ҚХР, 800 Dongchuan Road, Shanghai, 200240
S. Li
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
ҚХР, 800 Dongchuan Road, Shanghai, 200240
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