Synthesis and Cytotoxicity of 1,4-Naphthoquinone Oxime Derivatives
- 作者: Zhang Q.1, Dong J.1, Meng Q.1, Huang G.1, Li S.1
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隶属关系:
- School of Pharmacy
- 期: 卷 88, 编号 11 (2018)
- 页面: 2388-2393
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222547
- DOI: https://doi.org/10.1134/S1070363218110221
- ID: 222547
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详细
A series of hydroxylated 1,4-naphthoquinone oximes were designed and synthesized. The in vitro cytotoxicity of these compounds was evaluated against five human cancer cell lines and human skin fibroblast cell line. Among them, compounds (1E,4E)-6-{1-[(5-Hydroxypentyl)oxy]-2,2-dimethylbut-3-en-1-yl}-5,8- dimethoxynaphthalene-1,4-dione dioxime and (1E,4E)-6-{1-[(6-Hydroxyhexyl)oxy]-2,2-dimethylbut-3-en-1-yl}-5,8-dimethoxynaphthalene-1,4-dione dioxime displayed higher cytotoxicity in three cancer cell lines than the positive drug 5-fluorouracil
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作者简介
Q. Zhang
School of Pharmacy
编辑信件的主要联系方式.
Email: lianyi1126@sjtu.edu.cn
中国, 800 Dongchuan Road, Shanghai, 200240
J. Dong
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
中国, 800 Dongchuan Road, Shanghai, 200240
Q. Meng
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
中国, 800 Dongchuan Road, Shanghai, 200240
G. Huang
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
中国, 800 Dongchuan Road, Shanghai, 200240
S. Li
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
中国, 800 Dongchuan Road, Shanghai, 200240
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