Synthesis and Cytotoxicity of 1,4-Naphthoquinone Oxime Derivatives
- Авторы: Zhang Q.1, Dong J.1, Meng Q.1, Huang G.1, Li S.1
-
Учреждения:
- School of Pharmacy
- Выпуск: Том 88, № 11 (2018)
- Страницы: 2388-2393
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222547
- DOI: https://doi.org/10.1134/S1070363218110221
- ID: 222547
Цитировать
Аннотация
A series of hydroxylated 1,4-naphthoquinone oximes were designed and synthesized. The in vitro cytotoxicity of these compounds was evaluated against five human cancer cell lines and human skin fibroblast cell line. Among them, compounds (1E,4E)-6-{1-[(5-Hydroxypentyl)oxy]-2,2-dimethylbut-3-en-1-yl}-5,8- dimethoxynaphthalene-1,4-dione dioxime and (1E,4E)-6-{1-[(6-Hydroxyhexyl)oxy]-2,2-dimethylbut-3-en-1-yl}-5,8-dimethoxynaphthalene-1,4-dione dioxime displayed higher cytotoxicity in three cancer cell lines than the positive drug 5-fluorouracil
Ключевые слова
Об авторах
Q. Zhang
School of Pharmacy
Автор, ответственный за переписку.
Email: lianyi1126@sjtu.edu.cn
КНР, 800 Dongchuan Road, Shanghai, 200240
J. Dong
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
КНР, 800 Dongchuan Road, Shanghai, 200240
Q. Meng
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
КНР, 800 Dongchuan Road, Shanghai, 200240
G. Huang
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
КНР, 800 Dongchuan Road, Shanghai, 200240
S. Li
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
КНР, 800 Dongchuan Road, Shanghai, 200240
![](/img/style/loading.gif)