Synthesis and Cytotoxicity of 1,4-Naphthoquinone Oxime Derivatives
- Autores: Zhang Q.1, Dong J.1, Meng Q.1, Huang G.1, Li S.1
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Afiliações:
- School of Pharmacy
- Edição: Volume 88, Nº 11 (2018)
- Páginas: 2388-2393
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222547
- DOI: https://doi.org/10.1134/S1070363218110221
- ID: 222547
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Resumo
A series of hydroxylated 1,4-naphthoquinone oximes were designed and synthesized. The in vitro cytotoxicity of these compounds was evaluated against five human cancer cell lines and human skin fibroblast cell line. Among them, compounds (1E,4E)-6-{1-[(5-Hydroxypentyl)oxy]-2,2-dimethylbut-3-en-1-yl}-5,8- dimethoxynaphthalene-1,4-dione dioxime and (1E,4E)-6-{1-[(6-Hydroxyhexyl)oxy]-2,2-dimethylbut-3-en-1-yl}-5,8-dimethoxynaphthalene-1,4-dione dioxime displayed higher cytotoxicity in three cancer cell lines than the positive drug 5-fluorouracil
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Sobre autores
Q. Zhang
School of Pharmacy
Autor responsável pela correspondência
Email: lianyi1126@sjtu.edu.cn
República Popular da China, 800 Dongchuan Road, Shanghai, 200240
J. Dong
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
República Popular da China, 800 Dongchuan Road, Shanghai, 200240
Q. Meng
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
República Popular da China, 800 Dongchuan Road, Shanghai, 200240
G. Huang
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
República Popular da China, 800 Dongchuan Road, Shanghai, 200240
S. Li
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
República Popular da China, 800 Dongchuan Road, Shanghai, 200240
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