Synthesis and Cytotoxicity of 1,4-Naphthoquinone Oxime Derivatives
- Authors: Zhang Q.1, Dong J.1, Meng Q.1, Huang G.1, Li S.1
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Affiliations:
- School of Pharmacy
- Issue: Vol 88, No 11 (2018)
- Pages: 2388-2393
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222547
- DOI: https://doi.org/10.1134/S1070363218110221
- ID: 222547
Cite item
Abstract
A series of hydroxylated 1,4-naphthoquinone oximes were designed and synthesized. The in vitro cytotoxicity of these compounds was evaluated against five human cancer cell lines and human skin fibroblast cell line. Among them, compounds (1E,4E)-6-{1-[(5-Hydroxypentyl)oxy]-2,2-dimethylbut-3-en-1-yl}-5,8- dimethoxynaphthalene-1,4-dione dioxime and (1E,4E)-6-{1-[(6-Hydroxyhexyl)oxy]-2,2-dimethylbut-3-en-1-yl}-5,8-dimethoxynaphthalene-1,4-dione dioxime displayed higher cytotoxicity in three cancer cell lines than the positive drug 5-fluorouracil
Keywords
About the authors
Q. Zhang
School of Pharmacy
Author for correspondence.
Email: lianyi1126@sjtu.edu.cn
China, 800 Dongchuan Road, Shanghai, 200240
J. Dong
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
China, 800 Dongchuan Road, Shanghai, 200240
Q. Meng
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
China, 800 Dongchuan Road, Shanghai, 200240
G. Huang
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
China, 800 Dongchuan Road, Shanghai, 200240
S. Li
School of Pharmacy
Email: lianyi1126@sjtu.edu.cn
China, 800 Dongchuan Road, Shanghai, 200240
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