Email this article Synthesis of Lutein and Astaxanthin Esters and Their In Silico Activity
- Authors: Pechinskii S.V.1, Kuregyan A.G.1, Oganesyan E.T.1, Stepanova E.F.1
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Affiliations:
- Medical Pharmaceutical Institute of Pyatigorsk Branch of Volgograd Medical State University
- Issue: Vol 89, No 5 (2019)
- Pages: 913-917
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222899
- DOI: https://doi.org/10.1134/S1070363219050098
- ID: 222899
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Abstract
Esters of individual natural carotenoids lutein and astaxanthin with benzoic, 4-methylbenzoic, nicotinic, and mandelic acids have been synthesized. The esterification reaction of carotenoids has been carried out in an anhydrous medium at 37°C using of Novozyme 435 biocatalyst. The in silico prediction of the products activity by means of molecular docking has identified two compounds promising regarding the action towards the retinal protein Stard3 PDP code 5I9J.
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About the authors
S. V. Pechinskii
Medical Pharmaceutical Institute of Pyatigorsk Branch of Volgograd Medical State University
Author for correspondence.
Email: hplc@yandex.ru
Russian Federation, Pyatigorsk
A. G. Kuregyan
Medical Pharmaceutical Institute of Pyatigorsk Branch of Volgograd Medical State University
Email: hplc@yandex.ru
Russian Federation, Pyatigorsk
E. T. Oganesyan
Medical Pharmaceutical Institute of Pyatigorsk Branch of Volgograd Medical State University
Email: hplc@yandex.ru
Russian Federation, Pyatigorsk
E. F. Stepanova
Medical Pharmaceutical Institute of Pyatigorsk Branch of Volgograd Medical State University
Email: hplc@yandex.ru
Russian Federation, Pyatigorsk
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