Enviar artigo por via de e-mail Synthesis of Lutein and Astaxanthin Esters and Their In Silico Activity
- Autores: Pechinskii S.1, Kuregyan A.1, Oganesyan E.1, Stepanova E.1
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Afiliações:
- Medical Pharmaceutical Institute of Pyatigorsk Branch of Volgograd Medical State University
- Edição: Volume 89, Nº 5 (2019)
- Páginas: 913-917
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222899
- DOI: https://doi.org/10.1134/S1070363219050098
- ID: 222899
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Resumo
Esters of individual natural carotenoids lutein and astaxanthin with benzoic, 4-methylbenzoic, nicotinic, and mandelic acids have been synthesized. The esterification reaction of carotenoids has been carried out in an anhydrous medium at 37°C using of Novozyme 435 biocatalyst. The in silico prediction of the products activity by means of molecular docking has identified two compounds promising regarding the action towards the retinal protein Stard3 PDP code 5I9J.
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Sobre autores
S. Pechinskii
Medical Pharmaceutical Institute of Pyatigorsk Branch of Volgograd Medical State University
Autor responsável pela correspondência
Email: hplc@yandex.ru
Rússia, Pyatigorsk
A. Kuregyan
Medical Pharmaceutical Institute of Pyatigorsk Branch of Volgograd Medical State University
Email: hplc@yandex.ru
Rússia, Pyatigorsk
E. Oganesyan
Medical Pharmaceutical Institute of Pyatigorsk Branch of Volgograd Medical State University
Email: hplc@yandex.ru
Rússia, Pyatigorsk
E. Stepanova
Medical Pharmaceutical Institute of Pyatigorsk Branch of Volgograd Medical State University
Email: hplc@yandex.ru
Rússia, Pyatigorsk
