Synthesis of Lutein and Astaxanthin Esters and Their In Silico Activity
- Авторы: Pechinskii S.1, Kuregyan A.1, Oganesyan E.1, Stepanova E.1
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Учреждения:
- Medical Pharmaceutical Institute of Pyatigorsk Branch of Volgograd Medical State University
- Выпуск: Том 89, № 5 (2019)
- Страницы: 913-917
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222899
- DOI: https://doi.org/10.1134/S1070363219050098
- ID: 222899
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Аннотация
Esters of individual natural carotenoids lutein and astaxanthin with benzoic, 4-methylbenzoic, nicotinic, and mandelic acids have been synthesized. The esterification reaction of carotenoids has been carried out in an anhydrous medium at 37°C using of Novozyme 435 biocatalyst. The in silico prediction of the products activity by means of molecular docking has identified two compounds promising regarding the action towards the retinal protein Stard3 PDP code 5I9J.
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Об авторах
S. Pechinskii
Medical Pharmaceutical Institute of Pyatigorsk Branch of Volgograd Medical State University
Автор, ответственный за переписку.
Email: hplc@yandex.ru
Россия, Pyatigorsk
A. Kuregyan
Medical Pharmaceutical Institute of Pyatigorsk Branch of Volgograd Medical State University
Email: hplc@yandex.ru
Россия, Pyatigorsk
E. Oganesyan
Medical Pharmaceutical Institute of Pyatigorsk Branch of Volgograd Medical State University
Email: hplc@yandex.ru
Россия, Pyatigorsk
E. Stepanova
Medical Pharmaceutical Institute of Pyatigorsk Branch of Volgograd Medical State University
Email: hplc@yandex.ru
Россия, Pyatigorsk