Design, Synthesis, and Evaluation of Isoxazole-Thiadiazole Linked Carbazole Hybrids as Anticancer Agents
- 作者: Durga Rao B.1, Sreenivasulu R.2, Basaveswara Rao M.1
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隶属关系:
- Department of Chemistry
- Department of Chemistry, University College of Engineering (Autonomous)
- 期: 卷 89, 编号 10 (2019)
- 页面: 2115-2120
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223126
- DOI: https://doi.org/10.1134/S1070363219100207
- ID: 223126
如何引用文章
详细
A series of isoxazole-thiadiazole linked carbazole derivatives 12a–12j are synthesized and their chemical structures confirmed by 1H and 13C NMR and mass spectra. The products are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), DU-145 (prostate), and MDA MB-231 (breast) by using MTT assay and etoposide as a reference drug. The accumulated data indicate that most of the compounds demonstrate anticancer activity higher than etoposide.
作者简介
B. Durga Rao
Department of Chemistry
Email: professormandava@gmail.com
印度, Machilipatnam, Andhra Pradesh, 521001
R. Sreenivasulu
Department of Chemistry, University College of Engineering (Autonomous)
Email: professormandava@gmail.com
印度, Kakinada, Andhra Pradesh, 533003
M. Basaveswara Rao
Department of Chemistry
编辑信件的主要联系方式.
Email: professormandava@gmail.com
印度, Machilipatnam, Andhra Pradesh, 521001
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