Email this article Design, Synthesis, and Evaluation of Isoxazole-Thiadiazole Linked Carbazole Hybrids as Anticancer Agents
- Authors: Durga Rao B.V.1, Sreenivasulu R.2, Basaveswara Rao M.V.1
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Affiliations:
- Department of Chemistry
- Department of Chemistry, University College of Engineering (Autonomous)
- Issue: Vol 89, No 10 (2019)
- Pages: 2115-2120
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223126
- DOI: https://doi.org/10.1134/S1070363219100207
- ID: 223126
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Abstract
A series of isoxazole-thiadiazole linked carbazole derivatives 12a–12j are synthesized and their chemical structures confirmed by 1H and 13C NMR and mass spectra. The products are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), DU-145 (prostate), and MDA MB-231 (breast) by using MTT assay and etoposide as a reference drug. The accumulated data indicate that most of the compounds demonstrate anticancer activity higher than etoposide.
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About the authors
B. V. Durga Rao
Department of Chemistry
Email: professormandava@gmail.com
India, Machilipatnam, Andhra Pradesh, 521001
R. Sreenivasulu
Department of Chemistry, University College of Engineering (Autonomous)
Email: professormandava@gmail.com
India, Kakinada, Andhra Pradesh, 533003
M. V. Basaveswara Rao
Department of Chemistry
Author for correspondence.
Email: professormandava@gmail.com
India, Machilipatnam, Andhra Pradesh, 521001
