Design, Synthesis, and Evaluation of Isoxazole-Thiadiazole Linked Carbazole Hybrids as Anticancer Agents
- Авторлар: Durga Rao B.1, Sreenivasulu R.2, Basaveswara Rao M.1
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Мекемелер:
- Department of Chemistry
- Department of Chemistry, University College of Engineering (Autonomous)
- Шығарылым: Том 89, № 10 (2019)
- Беттер: 2115-2120
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223126
- DOI: https://doi.org/10.1134/S1070363219100207
- ID: 223126
Дәйексөз келтіру
Аннотация
A series of isoxazole-thiadiazole linked carbazole derivatives 12a–12j are synthesized and their chemical structures confirmed by 1H and 13C NMR and mass spectra. The products are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), DU-145 (prostate), and MDA MB-231 (breast) by using MTT assay and etoposide as a reference drug. The accumulated data indicate that most of the compounds demonstrate anticancer activity higher than etoposide.
Негізгі сөздер
Авторлар туралы
B. Durga Rao
Department of Chemistry
Email: professormandava@gmail.com
Үндістан, Machilipatnam, Andhra Pradesh, 521001
R. Sreenivasulu
Department of Chemistry, University College of Engineering (Autonomous)
Email: professormandava@gmail.com
Үндістан, Kakinada, Andhra Pradesh, 533003
M. Basaveswara Rao
Department of Chemistry
Хат алмасуға жауапты Автор.
Email: professormandava@gmail.com
Үндістан, Machilipatnam, Andhra Pradesh, 521001