Design, Synthesis, and Anticancer Evaluation of 2-{3-{4-[(5-Aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-trimethylphenyl)thiazol-4-amine Derivatives
- 作者: Yakantham T.1, Sreenivasulu R.1, Raju R.1
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隶属关系:
- Department of Chemistry
- 期: 卷 89, 编号 7 (2019)
- 页面: 1485-1490
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222997
- DOI: https://doi.org/10.1134/S1070363219070181
- ID: 222997
如何引用文章
详细
A series of new 2-{3-{4-[(5-aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-tri-methylphenyl)thiazol-4-amine derivatives is synthesized, and the structures of products are confirmed by 1H and 13C NMR, and mass spectra. The new compounds are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), Du-145 (prostate), and MDA MB-231 (breast) by using MTT assay and etoposide as a standard reference. All compounds demonstrate good to moderate activity on all cell lines.
作者简介
T. Yakantham
Department of Chemistry
Email: rrraju1@gmail.com
印度, Nagarjuna Nagar, Andhra Pradesh, 522510
R. Sreenivasulu
Department of Chemistry
Email: rrraju1@gmail.com
印度, Kakinada, Andhra Pradesh, 533003
R. Raju
Department of Chemistry
编辑信件的主要联系方式.
Email: rrraju1@gmail.com
印度, Nagarjuna Nagar, Andhra Pradesh, 522510