Design, Synthesis, and Anticancer Evaluation of 2-{3-{4-[(5-Aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-trimethylphenyl)thiazol-4-amine Derivatives
- Авторы: Yakantham T.1, Sreenivasulu R.1, Raju R.1
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Учреждения:
- Department of Chemistry
- Выпуск: Том 89, № 7 (2019)
- Страницы: 1485-1490
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222997
- DOI: https://doi.org/10.1134/S1070363219070181
- ID: 222997
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Аннотация
A series of new 2-{3-{4-[(5-aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-tri-methylphenyl)thiazol-4-amine derivatives is synthesized, and the structures of products are confirmed by 1H and 13C NMR, and mass spectra. The new compounds are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), Du-145 (prostate), and MDA MB-231 (breast) by using MTT assay and etoposide as a standard reference. All compounds demonstrate good to moderate activity on all cell lines.
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Об авторах
T. Yakantham
Department of Chemistry
Email: rrraju1@gmail.com
Индия, Nagarjuna Nagar, Andhra Pradesh, 522510
R. Sreenivasulu
Department of Chemistry
Email: rrraju1@gmail.com
Индия, Kakinada, Andhra Pradesh, 533003
R. Raju
Department of Chemistry
Автор, ответственный за переписку.
Email: rrraju1@gmail.com
Индия, Nagarjuna Nagar, Andhra Pradesh, 522510