Design, Synthesis, and Anticancer Evaluation of 2-{3-{4-[(5-Aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-trimethylphenyl)thiazol-4-amine Derivatives
- Авторлар: Yakantham T.1, Sreenivasulu R.1, Raju R.1
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Мекемелер:
- Department of Chemistry
- Шығарылым: Том 89, № 7 (2019)
- Беттер: 1485-1490
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222997
- DOI: https://doi.org/10.1134/S1070363219070181
- ID: 222997
Дәйексөз келтіру
Аннотация
A series of new 2-{3-{4-[(5-aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-tri-methylphenyl)thiazol-4-amine derivatives is synthesized, and the structures of products are confirmed by 1H and 13C NMR, and mass spectra. The new compounds are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), Du-145 (prostate), and MDA MB-231 (breast) by using MTT assay and etoposide as a standard reference. All compounds demonstrate good to moderate activity on all cell lines.
Негізгі сөздер
Авторлар туралы
T. Yakantham
Department of Chemistry
Email: rrraju1@gmail.com
Үндістан, Nagarjuna Nagar, Andhra Pradesh, 522510
R. Sreenivasulu
Department of Chemistry
Email: rrraju1@gmail.com
Үндістан, Kakinada, Andhra Pradesh, 533003
R. Raju
Department of Chemistry
Хат алмасуға жауапты Автор.
Email: rrraju1@gmail.com
Үндістан, Nagarjuna Nagar, Andhra Pradesh, 522510