Design, Synthesis, and Anticancer Evaluation of 2-{3-{4-[(5-Aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-trimethylphenyl)thiazol-4-amine Derivatives
- Authors: Yakantham T.1, Sreenivasulu R.1, Raju R.R.1
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Affiliations:
- Department of Chemistry
- Issue: Vol 89, No 7 (2019)
- Pages: 1485-1490
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222997
- DOI: https://doi.org/10.1134/S1070363219070181
- ID: 222997
Cite item
Abstract
A series of new 2-{3-{4-[(5-aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-tri-methylphenyl)thiazol-4-amine derivatives is synthesized, and the structures of products are confirmed by 1H and 13C NMR, and mass spectra. The new compounds are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), Du-145 (prostate), and MDA MB-231 (breast) by using MTT assay and etoposide as a standard reference. All compounds demonstrate good to moderate activity on all cell lines.
Keywords
About the authors
T. Yakantham
Department of Chemistry
Email: rrraju1@gmail.com
India, Nagarjuna Nagar, Andhra Pradesh, 522510
R. Sreenivasulu
Department of Chemistry
Email: rrraju1@gmail.com
India, Kakinada, Andhra Pradesh, 533003
R. R. Raju
Department of Chemistry
Author for correspondence.
Email: rrraju1@gmail.com
India, Nagarjuna Nagar, Andhra Pradesh, 522510