Design, Synthesis, and Anticancer Evaluation of 2-{3-{4-[(5-Aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-trimethylphenyl)thiazol-4-amine Derivatives
- Autores: Yakantham T.1, Sreenivasulu R.1, Raju R.1
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Afiliações:
- Department of Chemistry
- Edição: Volume 89, Nº 7 (2019)
- Páginas: 1485-1490
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222997
- DOI: https://doi.org/10.1134/S1070363219070181
- ID: 222997
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Resumo
A series of new 2-{3-{4-[(5-aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-tri-methylphenyl)thiazol-4-amine derivatives is synthesized, and the structures of products are confirmed by 1H and 13C NMR, and mass spectra. The new compounds are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), Du-145 (prostate), and MDA MB-231 (breast) by using MTT assay and etoposide as a standard reference. All compounds demonstrate good to moderate activity on all cell lines.
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Sobre autores
T. Yakantham
Department of Chemistry
Email: rrraju1@gmail.com
Índia, Nagarjuna Nagar, Andhra Pradesh, 522510
R. Sreenivasulu
Department of Chemistry
Email: rrraju1@gmail.com
Índia, Kakinada, Andhra Pradesh, 533003
R. Raju
Department of Chemistry
Autor responsável pela correspondência
Email: rrraju1@gmail.com
Índia, Nagarjuna Nagar, Andhra Pradesh, 522510