Synthesis and Antimicrobial Evaluation of Bis-3,5-disubstituted Isoxazoles Based Chalcones
- 作者: Sunitha V.1, Kumar A.2, Mahesh M.1, Shankaraiah P.2, Jalapathi P.1, Lincoln C.1
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隶属关系:
- Department of Chemistry
- Department of Humanities and Sciences
- 期: 卷 88, 编号 9 (2018)
- 页面: 1904-1911
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222427
- DOI: https://doi.org/10.1134/S1070363218090232
- ID: 222427
如何引用文章
详细
A series of bis-isoxazoles blended chalcones 7a–7j are synthesized in high yields. The combination of three pharmacologically active moieties in a single scaffold results in the synergistic effect in their bioactivity. All the newly synthesized compounds are characterized by IR, NMR and Mass spectroscopy. The target compounds 7a–7j are assessed for their antimicrobial activity and these demonstrate high to excellent activity against tested bacterial and fungal strains. The products 7f, 7h, 7j, and 7i demonstrate potent antimicrobial activity at concentrations 75 and 100 μg/mL.
作者简介
V. Sunitha
Department of Chemistry
编辑信件的主要联系方式.
Email: vinalasunitha@gmail.com
印度, Saifabad, Hyderabad, Telangana, 500004
A. Kumar
Department of Humanities and Sciences
Email: vinalasunitha@gmail.com
印度, Shamshabad, Hyderabad, Telangana, 501218
M. Mahesh
Department of Chemistry
Email: vinalasunitha@gmail.com
印度, Hyderabad, Telangana, 500007
P. Shankaraiah
Department of Humanities and Sciences
Email: vinalasunitha@gmail.com
印度, Shamshabad, Hyderabad, Telangana, 501218
P. Jalapathi
Department of Chemistry
Email: vinalasunitha@gmail.com
印度, Saifabad, Hyderabad, Telangana, 500004
Ch. Lincoln
Department of Chemistry
Email: vinalasunitha@gmail.com
印度, Hyderabad, Telangana, 500007