Synthesis and Antimicrobial Evaluation of Bis-3,5-disubstituted Isoxazoles Based Chalcones
- Авторы: Sunitha V.1, Kumar A.2, Mahesh M.1, Shankaraiah P.2, Jalapathi P.1, Lincoln C.1
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Учреждения:
- Department of Chemistry
- Department of Humanities and Sciences
- Выпуск: Том 88, № 9 (2018)
- Страницы: 1904-1911
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222427
- DOI: https://doi.org/10.1134/S1070363218090232
- ID: 222427
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Аннотация
A series of bis-isoxazoles blended chalcones 7a–7j are synthesized in high yields. The combination of three pharmacologically active moieties in a single scaffold results in the synergistic effect in their bioactivity. All the newly synthesized compounds are characterized by IR, NMR and Mass spectroscopy. The target compounds 7a–7j are assessed for their antimicrobial activity and these demonstrate high to excellent activity against tested bacterial and fungal strains. The products 7f, 7h, 7j, and 7i demonstrate potent antimicrobial activity at concentrations 75 and 100 μg/mL.
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Об авторах
V. Sunitha
Department of Chemistry
Автор, ответственный за переписку.
Email: vinalasunitha@gmail.com
Индия, Saifabad, Hyderabad, Telangana, 500004
A. Kumar
Department of Humanities and Sciences
Email: vinalasunitha@gmail.com
Индия, Shamshabad, Hyderabad, Telangana, 501218
M. Mahesh
Department of Chemistry
Email: vinalasunitha@gmail.com
Индия, Hyderabad, Telangana, 500007
P. Shankaraiah
Department of Humanities and Sciences
Email: vinalasunitha@gmail.com
Индия, Shamshabad, Hyderabad, Telangana, 501218
P. Jalapathi
Department of Chemistry
Email: vinalasunitha@gmail.com
Индия, Saifabad, Hyderabad, Telangana, 500004
Ch. Lincoln
Department of Chemistry
Email: vinalasunitha@gmail.com
Индия, Hyderabad, Telangana, 500007