Synthesis and Antimicrobial Evaluation of Bis-3,5-disubstituted Isoxazoles Based Chalcones
- Autores: Sunitha V.1, Kumar A.2, Mahesh M.1, Shankaraiah P.2, Jalapathi P.1, Lincoln C.1
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Afiliações:
- Department of Chemistry
- Department of Humanities and Sciences
- Edição: Volume 88, Nº 9 (2018)
- Páginas: 1904-1911
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222427
- DOI: https://doi.org/10.1134/S1070363218090232
- ID: 222427
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Resumo
A series of bis-isoxazoles blended chalcones 7a–7j are synthesized in high yields. The combination of three pharmacologically active moieties in a single scaffold results in the synergistic effect in their bioactivity. All the newly synthesized compounds are characterized by IR, NMR and Mass spectroscopy. The target compounds 7a–7j are assessed for their antimicrobial activity and these demonstrate high to excellent activity against tested bacterial and fungal strains. The products 7f, 7h, 7j, and 7i demonstrate potent antimicrobial activity at concentrations 75 and 100 μg/mL.
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Sobre autores
V. Sunitha
Department of Chemistry
Autor responsável pela correspondência
Email: vinalasunitha@gmail.com
Índia, Saifabad, Hyderabad, Telangana, 500004
A. Kumar
Department of Humanities and Sciences
Email: vinalasunitha@gmail.com
Índia, Shamshabad, Hyderabad, Telangana, 501218
M. Mahesh
Department of Chemistry
Email: vinalasunitha@gmail.com
Índia, Hyderabad, Telangana, 500007
P. Shankaraiah
Department of Humanities and Sciences
Email: vinalasunitha@gmail.com
Índia, Shamshabad, Hyderabad, Telangana, 501218
P. Jalapathi
Department of Chemistry
Email: vinalasunitha@gmail.com
Índia, Saifabad, Hyderabad, Telangana, 500004
Ch. Lincoln
Department of Chemistry
Email: vinalasunitha@gmail.com
Índia, Hyderabad, Telangana, 500007