Synthesis and Antimicrobial Evaluation of Bis-3,5-disubstituted Isoxazoles Based Chalcones
- Authors: Sunitha V.1, Kumar A.K.2, Mahesh M.1, Shankaraiah P.2, Jalapathi P.1, Lincoln C.A.1
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Affiliations:
- Department of Chemistry
- Department of Humanities and Sciences
- Issue: Vol 88, No 9 (2018)
- Pages: 1904-1911
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222427
- DOI: https://doi.org/10.1134/S1070363218090232
- ID: 222427
Cite item
Abstract
A series of bis-isoxazoles blended chalcones 7a–7j are synthesized in high yields. The combination of three pharmacologically active moieties in a single scaffold results in the synergistic effect in their bioactivity. All the newly synthesized compounds are characterized by IR, NMR and Mass spectroscopy. The target compounds 7a–7j are assessed for their antimicrobial activity and these demonstrate high to excellent activity against tested bacterial and fungal strains. The products 7f, 7h, 7j, and 7i demonstrate potent antimicrobial activity at concentrations 75 and 100 μg/mL.
About the authors
V. Sunitha
Department of Chemistry
Author for correspondence.
Email: vinalasunitha@gmail.com
India, Saifabad, Hyderabad, Telangana, 500004
A. Kishore Kumar
Department of Humanities and Sciences
Email: vinalasunitha@gmail.com
India, Shamshabad, Hyderabad, Telangana, 501218
M. Mahesh
Department of Chemistry
Email: vinalasunitha@gmail.com
India, Hyderabad, Telangana, 500007
P. Shankaraiah
Department of Humanities and Sciences
Email: vinalasunitha@gmail.com
India, Shamshabad, Hyderabad, Telangana, 501218
P. Jalapathi
Department of Chemistry
Email: vinalasunitha@gmail.com
India, Saifabad, Hyderabad, Telangana, 500004
Ch. Abraham Lincoln
Department of Chemistry
Email: vinalasunitha@gmail.com
India, Hyderabad, Telangana, 500007