Synthesis and Antimicrobial Evaluation of Bis-3,5-disubstituted Isoxazoles Based Chalcones
- Авторлар: Sunitha V.1, Kumar A.2, Mahesh M.1, Shankaraiah P.2, Jalapathi P.1, Lincoln C.1
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Мекемелер:
- Department of Chemistry
- Department of Humanities and Sciences
- Шығарылым: Том 88, № 9 (2018)
- Беттер: 1904-1911
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222427
- DOI: https://doi.org/10.1134/S1070363218090232
- ID: 222427
Дәйексөз келтіру
Аннотация
A series of bis-isoxazoles blended chalcones 7a–7j are synthesized in high yields. The combination of three pharmacologically active moieties in a single scaffold results in the synergistic effect in their bioactivity. All the newly synthesized compounds are characterized by IR, NMR and Mass spectroscopy. The target compounds 7a–7j are assessed for their antimicrobial activity and these demonstrate high to excellent activity against tested bacterial and fungal strains. The products 7f, 7h, 7j, and 7i demonstrate potent antimicrobial activity at concentrations 75 and 100 μg/mL.
Негізгі сөздер
Авторлар туралы
V. Sunitha
Department of Chemistry
Хат алмасуға жауапты Автор.
Email: vinalasunitha@gmail.com
Үндістан, Saifabad, Hyderabad, Telangana, 500004
A. Kumar
Department of Humanities and Sciences
Email: vinalasunitha@gmail.com
Үндістан, Shamshabad, Hyderabad, Telangana, 501218
M. Mahesh
Department of Chemistry
Email: vinalasunitha@gmail.com
Үндістан, Hyderabad, Telangana, 500007
P. Shankaraiah
Department of Humanities and Sciences
Email: vinalasunitha@gmail.com
Үндістан, Shamshabad, Hyderabad, Telangana, 501218
P. Jalapathi
Department of Chemistry
Email: vinalasunitha@gmail.com
Үндістан, Saifabad, Hyderabad, Telangana, 500004
Ch. Lincoln
Department of Chemistry
Email: vinalasunitha@gmail.com
Үндістан, Hyderabad, Telangana, 500007