Modification of Polymyxin B1 by Water-Soluble Functional Copolymers of Vinyl Alcohol


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The condensation of the peptide antibiotic Polymyxin В1 with the vinyl alcohol copolymers containing aldehyde groups was studied. The structure and composition of the resulting conjugates were determined. The polymer derivatives of the antibiotic were shown to preserve their antimicrobial activity.

作者简介

V. Shalygina

Institute of Macromolecular Compounds

编辑信件的主要联系方式.
Email: shalygina@hq.macro.ru
俄罗斯联邦, Bol’shoi pr. V.O. 31, St. Petersburg, 199004

E. Vlasova

Institute of Macromolecular Compounds

Email: shalygina@hq.macro.ru
俄罗斯联邦, Bol’shoi pr. V.O. 31, St. Petersburg, 199004

V. Gaydukova

St. Petersburg State Pharmaceutical Academy

Email: shalygina@hq.macro.ru
俄罗斯联邦, St. Petersburg

E. Anan’eva

St. Petersburg State Pharmaceutical Academy

Email: shalygina@hq.macro.ru
俄罗斯联邦, St. Petersburg

E. Panarin

Institute of Macromolecular Compounds; Petr Velikii State Polytechnical University

Email: shalygina@hq.macro.ru
俄罗斯联邦, Bol’shoi pr. V.O. 31, St. Petersburg, 199004; St. Petersburg


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