Modification of Polymyxin B 1  by Water-Soluble Functional Copolymers of Vinyl Alcohol

V. V. Shalygina; E. N. Vlasova; V. A. Gaydukova; E. P. Anan’eva; E. F. Panarin

doi:10.1134/S1070363218060233

Modification of Polymyxin B₁ by Water-Soluble Functional Copolymers of Vinyl Alcohol

Authors: Shalygina V.V.¹, Vlasova E.N.¹, Gaydukova V.A.², Anan’eva E.P.², Panarin E.F.¹^,3
Affiliations:
1. Institute of Macromolecular Compounds
2. St. Petersburg State Pharmaceutical Academy
3. Petr Velikii State Polytechnical University
Issue: Vol 88, No 6 (2018)
Pages: 1194-1198
Section: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222255
DOI: https://doi.org/10.1134/S1070363218060233
ID: 222255

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Abstract
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Abstract

The condensation of the peptide antibiotic Polymyxin В₁ with the vinyl alcohol copolymers containing aldehyde groups was studied. The structure and composition of the resulting conjugates were determined. The polymer derivatives of the antibiotic were shown to preserve their antimicrobial activity.

Keywords

Polymyxin В, vinyl alcohol, copolymers, conjugate, biological activity

About the authors

V. V. Shalygina

Institute of Macromolecular Compounds

Author for correspondence.
Email: shalygina@hq.macro.ru
Russian Federation, Bol’shoi pr. V.O. 31, St. Petersburg, 199004

E. N. Vlasova

Institute of Macromolecular Compounds

Email: shalygina@hq.macro.ru
Russian Federation, Bol’shoi pr. V.O. 31, St. Petersburg, 199004

V. A. Gaydukova

St. Petersburg State Pharmaceutical Academy

Email: shalygina@hq.macro.ru
Russian Federation, St. Petersburg

E. P. Anan’eva