Modification of Polymyxin B 1  by Water-Soluble Functional Copolymers of Vinyl Alcohol

V. V. Shalygina; E. N. Vlasova; V. A. Gaydukova; E. P. Anan’eva; E. F. Panarin

doi:10.1134/S1070363218060233

Modification of Polymyxin B₁ by Water-Soluble Functional Copolymers of Vinyl Alcohol

Авторлар: Shalygina V.¹, Vlasova E.¹, Gaydukova V.², Anan’eva E.², Panarin E.¹^,3
Мекемелер:
1. Institute of Macromolecular Compounds
2. St. Petersburg State Pharmaceutical Academy
3. Petr Velikii State Polytechnical University
Шығарылым: Том 88, № 6 (2018)
Беттер: 1194-1198
Бөлім: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222255
DOI: https://doi.org/10.1134/S1070363218060233
ID: 222255

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Аннотация

The condensation of the peptide antibiotic Polymyxin В₁ with the vinyl alcohol copolymers containing aldehyde groups was studied. The structure and composition of the resulting conjugates were determined. The polymer derivatives of the antibiotic were shown to preserve their antimicrobial activity.

Негізгі сөздер

Polymyxin В, vinyl alcohol, copolymers, conjugate, biological activity

Авторлар туралы

V. Shalygina

Institute of Macromolecular Compounds

Хат алмасуға жауапты Автор.
Email: shalygina@hq.macro.ru
Ресей, Bol’shoi pr. V.O. 31, St. Petersburg, 199004

E. Vlasova

Institute of Macromolecular Compounds

Email: shalygina@hq.macro.ru
Ресей, Bol’shoi pr. V.O. 31, St. Petersburg, 199004

V. Gaydukova

St. Petersburg State Pharmaceutical Academy

Email: shalygina@hq.macro.ru
Ресей, St. Petersburg

E. Anan’eva