Modification of Polymyxin B 1  by Water-Soluble Functional Copolymers of Vinyl Alcohol

V. V. Shalygina; E. N. Vlasova; V. A. Gaydukova; E. P. Anan’eva; E. F. Panarin

doi:10.1134/S1070363218060233

Modification of Polymyxin B₁ by Water-Soluble Functional Copolymers of Vinyl Alcohol

Autores: Shalygina V.¹, Vlasova E.¹, Gaydukova V.², Anan’eva E.², Panarin E.¹^,3
Afiliações:
1. Institute of Macromolecular Compounds
2. St. Petersburg State Pharmaceutical Academy
3. Petr Velikii State Polytechnical University
Edição: Volume 88, Nº 6 (2018)
Páginas: 1194-1198
Seção: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222255
DOI: https://doi.org/10.1134/S1070363218060233
ID: 222255

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Resumo

The condensation of the peptide antibiotic Polymyxin В₁ with the vinyl alcohol copolymers containing aldehyde groups was studied. The structure and composition of the resulting conjugates were determined. The polymer derivatives of the antibiotic were shown to preserve their antimicrobial activity.

Palavras-chave

Polymyxin В, vinyl alcohol, copolymers, conjugate, biological activity

Sobre autores

V. Shalygina

Institute of Macromolecular Compounds

Autor responsável pela correspondência
Email: shalygina@hq.macro.ru
Rússia, Bol’shoi pr. V.O. 31, St. Petersburg, 199004

E. Vlasova

Institute of Macromolecular Compounds

Email: shalygina@hq.macro.ru
Rússia, Bol’shoi pr. V.O. 31, St. Petersburg, 199004

V. Gaydukova

St. Petersburg State Pharmaceutical Academy

Email: shalygina@hq.macro.ru
Rússia, St. Petersburg

E. Anan’eva