Synthesis and Cytotoxicity of 6-Substituted 1,4-Naphthoquinone Oxime Derivatives (II)
- Авторы: Huang G.1, Zhao H.2, Li S.1
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Учреждения:
- School of Pharmacy
- School of Pharmaceutical Sciences and Chemistry
- Выпуск: Том 87, № 12 (2017)
- Страницы: 2979-2985
- Раздел: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/221797
- DOI: https://doi.org/10.1134/S1070363217120416
- ID: 221797
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Аннотация
In the present study, a series of 1,4-naphthoquinone oxime derivatives has been synthesized. The structures were confirmed by spectroscopic methods. The newly synthesized compounds were evaluated for their in vitro cytotoxicity. Among those, the compounds 8c, 8d, 8e, 12a, and 12b demonstrated potent cytotoxic activity comparable with that of the reference drug 5-Fu.
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Об авторах
G. Huang
School of Pharmacy
Автор, ответственный за переписку.
Email: guanghuangmedchem@hotmail.com
КНР, Shanghai, 200240
H. Zhao
School of Pharmaceutical Sciences and Chemistry
Email: ssli@sjtu.edu.cn
КНР, Dali, 671000
S. Li
School of Pharmacy
Автор, ответственный за переписку.
Email: ssli@sjtu.edu.cn
КНР, Shanghai, 200240
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