Email this article Synthesis and Cytotoxicity of 6-Substituted 1,4-Naphthoquinone Oxime Derivatives (II)
- Authors: Huang G.1, Zhao H.R.2, Li S.S.1
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Affiliations:
- School of Pharmacy
- School of Pharmaceutical Sciences and Chemistry
- Issue: Vol 87, No 12 (2017)
- Pages: 2979-2985
- Section: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/221797
- DOI: https://doi.org/10.1134/S1070363217120416
- ID: 221797
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Abstract
In the present study, a series of 1,4-naphthoquinone oxime derivatives has been synthesized. The structures were confirmed by spectroscopic methods. The newly synthesized compounds were evaluated for their in vitro cytotoxicity. Among those, the compounds 8c, 8d, 8e, 12a, and 12b demonstrated potent cytotoxic activity comparable with that of the reference drug 5-Fu.
About the authors
G. Huang
School of Pharmacy
Author for correspondence.
Email: guanghuangmedchem@hotmail.com
China, Shanghai, 200240
H. R. Zhao
School of Pharmaceutical Sciences and Chemistry
Email: ssli@sjtu.edu.cn
China, Dali, 671000
S. S. Li
School of Pharmacy
Author for correspondence.
Email: ssli@sjtu.edu.cn
China, Shanghai, 200240
