Three-Component One-Pot Synthesis of New 2,5,6,7- and 2,5,8,10-Substituted Pyrimido[4,5-b]quinoline-4,6-diones and -2,4,6-Triones
- Autores: Hovsepyan T.1, Karakhanyan G.1, Israelyan S.1, Panosyan G.2
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Afiliações:
- Mnjhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
- Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
- Edição: Volume 88, Nº 6 (2018)
- Páginas: 1114-1119
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222238
- DOI: https://doi.org/10.1134/S1070363218060117
- ID: 222238
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Resumo
A series of new pyrimido[4,5-b]quinoline derivatives was synthesized by three-component cyclocondensation of 2-R1-6-aminopyrimidine-4-ones, 5,5-dimethylcyclohexane-1,3-dione (dimedone), and aromatic or heterocyclic aldehydes in a water medium in the presence of triethylbenzylammonium chloride. The replacement of the primary amino group in the position 6 of the key 6-aminopyrimidin-4-one with the secondary amino group led to the formation of 10-substituted analogs of pyrimido[4,5-b]quinolines which are of interest for biological screening.
Sobre autores
T. Hovsepyan
Mnjhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Autor responsável pela correspondência
Email: tag.hovsepyan@mail.ru
Armênia, pr. Azatutyan 26, Yerevan, 0014
G. Karakhanyan
Mnjhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Armênia, pr. Azatutyan 26, Yerevan, 0014
S. Israelyan
Mnjhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Armênia, pr. Azatutyan 26, Yerevan, 0014
G. Panosyan
Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Armênia, Yerevan