Three-Component One-Pot Synthesis of New 2,5,6,7- and 2,5,8,10-Substituted Pyrimido[4,5-b]quinoline-4,6-diones and -2,4,6-Triones
- Авторлар: Hovsepyan T.1, Karakhanyan G.1, Israelyan S.1, Panosyan G.2
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Мекемелер:
- Mnjhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
- Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
- Шығарылым: Том 88, № 6 (2018)
- Беттер: 1114-1119
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222238
- DOI: https://doi.org/10.1134/S1070363218060117
- ID: 222238
Дәйексөз келтіру
Аннотация
A series of new pyrimido[4,5-b]quinoline derivatives was synthesized by three-component cyclocondensation of 2-R1-6-aminopyrimidine-4-ones, 5,5-dimethylcyclohexane-1,3-dione (dimedone), and aromatic or heterocyclic aldehydes in a water medium in the presence of triethylbenzylammonium chloride. The replacement of the primary amino group in the position 6 of the key 6-aminopyrimidin-4-one with the secondary amino group led to the formation of 10-substituted analogs of pyrimido[4,5-b]quinolines which are of interest for biological screening.
Авторлар туралы
T. Hovsepyan
Mnjhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Хат алмасуға жауапты Автор.
Email: tag.hovsepyan@mail.ru
Армения, pr. Azatutyan 26, Yerevan, 0014
G. Karakhanyan
Mnjhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Армения, pr. Azatutyan 26, Yerevan, 0014
S. Israelyan
Mnjhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Армения, pr. Azatutyan 26, Yerevan, 0014
G. Panosyan
Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Армения, Yerevan