Three-Component One-Pot Synthesis of New 2,5,6,7- and 2,5,8,10-Substituted Pyrimido[4,5-b]quinoline-4,6-diones and -2,4,6-Triones

Abstract

A series of new pyrimido[4,5-b]quinoline derivatives was synthesized by three-component cyclocondensation of 2-R¹-6-aminopyrimidine-4-ones, 5,5-dimethylcyclohexane-1,3-dione (dimedone), and aromatic or heterocyclic aldehydes in a water medium in the presence of triethylbenzylammonium chloride. The replacement of the primary amino group in the position 6 of the key 6-aminopyrimidin-4-one with the secondary amino group led to the formation of 10-substituted analogs of pyrimido[4,5-b]quinolines which are of interest for biological screening.