Three-Component One-Pot Synthesis of New 2,5,6,7- and 2,5,8,10-Substituted Pyrimido[4,5-b]quinoline-4,6-diones and -2,4,6-Triones
- 作者: Hovsepyan T.1, Karakhanyan G.1, Israelyan S.1, Panosyan G.2
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隶属关系:
- Mnjhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
- Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
- 期: 卷 88, 编号 6 (2018)
- 页面: 1114-1119
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222238
- DOI: https://doi.org/10.1134/S1070363218060117
- ID: 222238
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详细
A series of new pyrimido[4,5-b]quinoline derivatives was synthesized by three-component cyclocondensation of 2-R1-6-aminopyrimidine-4-ones, 5,5-dimethylcyclohexane-1,3-dione (dimedone), and aromatic or heterocyclic aldehydes in a water medium in the presence of triethylbenzylammonium chloride. The replacement of the primary amino group in the position 6 of the key 6-aminopyrimidin-4-one with the secondary amino group led to the formation of 10-substituted analogs of pyrimido[4,5-b]quinolines which are of interest for biological screening.
作者简介
T. Hovsepyan
Mnjhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
编辑信件的主要联系方式.
Email: tag.hovsepyan@mail.ru
亚美尼亚, pr. Azatutyan 26, Yerevan, 0014
G. Karakhanyan
Mnjhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
亚美尼亚, pr. Azatutyan 26, Yerevan, 0014
S. Israelyan
Mnjhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
亚美尼亚, pr. Azatutyan 26, Yerevan, 0014
G. Panosyan
Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
亚美尼亚, Yerevan