Synthesis and Wittig Reaction of Formylated (Trifluoromethylfuryl)methanephosphonates
- Autores: Doronina E.1, Pevzner L.1, Polukeev V.2, Petrov M.1
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Afiliações:
- St. Petersburg Institute of Technology (Technical University)
- Institute of Experimental Medicine
- Edição: Volume 88, Nº 2 (2018)
- Páginas: 241-250
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221991
- DOI: https://doi.org/10.1134/S1070363218020093
- ID: 221991
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Resumo
Methods of synthesis of 4-functionalyzed (5-trifluoromethylfur-2-yl)methanephosphonates and (5-methyl-2-trifluoromethylfur-3-yl)methanephosphonate are developed. Their formylation with ethyl formate in the presence of sodium foil is studied. Spectral characteristics of tautomers of obtained derivatives of phosphonoacetic aldehyde are evaluated. It is shown that interaction of obtained formyl derivatives with ethoxycarbonylmethylenetriphenylphosphorane regardless of the structure of the furan fragment leads to 4-furylsubstituted alkyl 4-(diethoxyphosphoryl)but-3-enoate, the abnormal product of Wittig reaction.
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Sobre autores
E. Doronina
St. Petersburg Institute of Technology (Technical University)
Email: pevzner_lm@list.ru
Rússia, Moskovskii pr. 26, St. Petersburg, 190013
L. Pevzner
St. Petersburg Institute of Technology (Technical University)
Autor responsável pela correspondência
Email: pevzner_lm@list.ru
Rússia, Moskovskii pr. 26, St. Petersburg, 190013
V. Polukeev
Institute of Experimental Medicine
Email: pevzner_lm@list.ru
Rússia, St. Petersburg
M. Petrov
St. Petersburg Institute of Technology (Technical University)
Email: pevzner_lm@list.ru
Rússia, Moskovskii pr. 26, St. Petersburg, 190013
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