Synthesis and Wittig Reaction of Formylated (Trifluoromethylfuryl)methanephosphonates
- Авторы: Doronina E.1, Pevzner L.1, Polukeev V.2, Petrov M.1
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Учреждения:
- St. Petersburg Institute of Technology (Technical University)
- Institute of Experimental Medicine
- Выпуск: Том 88, № 2 (2018)
- Страницы: 241-250
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221991
- DOI: https://doi.org/10.1134/S1070363218020093
- ID: 221991
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Аннотация
Methods of synthesis of 4-functionalyzed (5-trifluoromethylfur-2-yl)methanephosphonates and (5-methyl-2-trifluoromethylfur-3-yl)methanephosphonate are developed. Their formylation with ethyl formate in the presence of sodium foil is studied. Spectral characteristics of tautomers of obtained derivatives of phosphonoacetic aldehyde are evaluated. It is shown that interaction of obtained formyl derivatives with ethoxycarbonylmethylenetriphenylphosphorane regardless of the structure of the furan fragment leads to 4-furylsubstituted alkyl 4-(diethoxyphosphoryl)but-3-enoate, the abnormal product of Wittig reaction.
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Об авторах
E. Doronina
St. Petersburg Institute of Technology (Technical University)
Email: pevzner_lm@list.ru
Россия, Moskovskii pr. 26, St. Petersburg, 190013
L. Pevzner
St. Petersburg Institute of Technology (Technical University)
Автор, ответственный за переписку.
Email: pevzner_lm@list.ru
Россия, Moskovskii pr. 26, St. Petersburg, 190013
V. Polukeev
Institute of Experimental Medicine
Email: pevzner_lm@list.ru
Россия, St. Petersburg
M. Petrov
St. Petersburg Institute of Technology (Technical University)
Email: pevzner_lm@list.ru
Россия, Moskovskii pr. 26, St. Petersburg, 190013
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