Synthesis and Wittig Reaction of Formylated (Trifluoromethylfuryl)methanephosphonates
- Авторлар: Doronina E.1, Pevzner L.1, Polukeev V.2, Petrov M.1
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Мекемелер:
- St. Petersburg Institute of Technology (Technical University)
- Institute of Experimental Medicine
- Шығарылым: Том 88, № 2 (2018)
- Беттер: 241-250
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221991
- DOI: https://doi.org/10.1134/S1070363218020093
- ID: 221991
Дәйексөз келтіру
Аннотация
Methods of synthesis of 4-functionalyzed (5-trifluoromethylfur-2-yl)methanephosphonates and (5-methyl-2-trifluoromethylfur-3-yl)methanephosphonate are developed. Their formylation with ethyl formate in the presence of sodium foil is studied. Spectral characteristics of tautomers of obtained derivatives of phosphonoacetic aldehyde are evaluated. It is shown that interaction of obtained formyl derivatives with ethoxycarbonylmethylenetriphenylphosphorane regardless of the structure of the furan fragment leads to 4-furylsubstituted alkyl 4-(diethoxyphosphoryl)but-3-enoate, the abnormal product of Wittig reaction.
Негізгі сөздер
Авторлар туралы
E. Doronina
St. Petersburg Institute of Technology (Technical University)
Email: pevzner_lm@list.ru
Ресей, Moskovskii pr. 26, St. Petersburg, 190013
L. Pevzner
St. Petersburg Institute of Technology (Technical University)
Хат алмасуға жауапты Автор.
Email: pevzner_lm@list.ru
Ресей, Moskovskii pr. 26, St. Petersburg, 190013
V. Polukeev
Institute of Experimental Medicine
Email: pevzner_lm@list.ru
Ресей, St. Petersburg
M. Petrov
St. Petersburg Institute of Technology (Technical University)
Email: pevzner_lm@list.ru
Ресей, Moskovskii pr. 26, St. Petersburg, 190013
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