Synthesis and Wittig Reaction of Formylated (Trifluoromethylfuryl)methanephosphonates
- 作者: Doronina E.1, Pevzner L.1, Polukeev V.2, Petrov M.1
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隶属关系:
- St. Petersburg Institute of Technology (Technical University)
- Institute of Experimental Medicine
- 期: 卷 88, 编号 2 (2018)
- 页面: 241-250
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221991
- DOI: https://doi.org/10.1134/S1070363218020093
- ID: 221991
如何引用文章
详细
Methods of synthesis of 4-functionalyzed (5-trifluoromethylfur-2-yl)methanephosphonates and (5-methyl-2-trifluoromethylfur-3-yl)methanephosphonate are developed. Their formylation with ethyl formate in the presence of sodium foil is studied. Spectral characteristics of tautomers of obtained derivatives of phosphonoacetic aldehyde are evaluated. It is shown that interaction of obtained formyl derivatives with ethoxycarbonylmethylenetriphenylphosphorane regardless of the structure of the furan fragment leads to 4-furylsubstituted alkyl 4-(diethoxyphosphoryl)but-3-enoate, the abnormal product of Wittig reaction.
作者简介
E. Doronina
St. Petersburg Institute of Technology (Technical University)
Email: pevzner_lm@list.ru
俄罗斯联邦, Moskovskii pr. 26, St. Petersburg, 190013
L. Pevzner
St. Petersburg Institute of Technology (Technical University)
编辑信件的主要联系方式.
Email: pevzner_lm@list.ru
俄罗斯联邦, Moskovskii pr. 26, St. Petersburg, 190013
V. Polukeev
Institute of Experimental Medicine
Email: pevzner_lm@list.ru
俄罗斯联邦, St. Petersburg
M. Petrov
St. Petersburg Institute of Technology (Technical University)
Email: pevzner_lm@list.ru
俄罗斯联邦, Moskovskii pr. 26, St. Petersburg, 190013
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