Enantioselective synthesis of (S)-1-phenylethanol, a precursor to low-molecular-weight bioregulators
- Autores: Chanysheva A.1, Yunusova G.1, Vorobyova T.1, Zorin V.1
-
Afiliações:
- Ufa State Petroleum Technological University
- Edição: Volume 86, Nº 13 (2016)
- Páginas: 3021-3024
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/217752
- DOI: https://doi.org/10.1134/S107036321613017X
- ID: 217752
Citar
Resumo
A procedure has been proposed for the synthesis of (S)-(–)-1-phenylethanol, an important building block for the preparation of medicinal agents possessing antidiabetic, antidepressant, and antirabic activity, as well as of antifeedants and antiparasitic, antimicrobial, and antifungal metabolites, by enantioselective bioreduction of acetophenone. Different exogenous reducing agents (propan-2-ol, ethanol, and glucose) were tried to improve the yield of the target product and its enantiomeric purity.
Sobre autores
A. Chanysheva
Ufa State Petroleum Technological University
Autor responsável pela correspondência
Email: aliyach@mail.ru
Rússia, ul. Kosmonavtov 1, Bashkortostan, Ufa, 450062
G. Yunusova
Ufa State Petroleum Technological University
Email: aliyach@mail.ru
Rússia, ul. Kosmonavtov 1, Bashkortostan, Ufa, 450062
T. Vorobyova
Ufa State Petroleum Technological University
Email: aliyach@mail.ru
Rússia, ul. Kosmonavtov 1, Bashkortostan, Ufa, 450062
V. Zorin
Ufa State Petroleum Technological University
Email: aliyach@mail.ru
Rússia, ul. Kosmonavtov 1, Bashkortostan, Ufa, 450062
![](/img/style/loading.gif)