Enantioselective synthesis of (S)-1-phenylethanol, a precursor to low-molecular-weight bioregulators
- Authors: Chanysheva A.R.1, Yunusova G.V.1, Vorobyova T.E.1, Zorin V.V.1
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Affiliations:
- Ufa State Petroleum Technological University
- Issue: Vol 86, No 13 (2016)
- Pages: 3021-3024
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/217752
- DOI: https://doi.org/10.1134/S107036321613017X
- ID: 217752
Cite item
Abstract
A procedure has been proposed for the synthesis of (S)-(–)-1-phenylethanol, an important building block for the preparation of medicinal agents possessing antidiabetic, antidepressant, and antirabic activity, as well as of antifeedants and antiparasitic, antimicrobial, and antifungal metabolites, by enantioselective bioreduction of acetophenone. Different exogenous reducing agents (propan-2-ol, ethanol, and glucose) were tried to improve the yield of the target product and its enantiomeric purity.
About the authors
A. R. Chanysheva
Ufa State Petroleum Technological University
Author for correspondence.
Email: aliyach@mail.ru
Russian Federation, ul. Kosmonavtov 1, Bashkortostan, Ufa, 450062
G. V. Yunusova
Ufa State Petroleum Technological University
Email: aliyach@mail.ru
Russian Federation, ul. Kosmonavtov 1, Bashkortostan, Ufa, 450062
T. E. Vorobyova
Ufa State Petroleum Technological University
Email: aliyach@mail.ru
Russian Federation, ul. Kosmonavtov 1, Bashkortostan, Ufa, 450062
V. V. Zorin
Ufa State Petroleum Technological University
Email: aliyach@mail.ru
Russian Federation, ul. Kosmonavtov 1, Bashkortostan, Ufa, 450062