Complex Formation of Cyclodextrins with Sulfasalazine in Buffer Solutions
- Авторлар: Kuranov D.1, Chibunova E.1, Volkova T.1, Terekhova I.1
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Мекемелер:
- G.A. Krestov Institute of Solution Chemistry
- Шығарылым: Том 88, № 6 (2018)
- Беттер: 1325-1330
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222287
- DOI: https://doi.org/10.1134/S1070363218060439
- ID: 222287
Дәйексөз келтіру
Аннотация
Complex formation of α-, β-, and γ-cyclodextrins with sulfasalazine in biologically relevant buffer solutions (pH 1.2 and 7.4) was studied. Formation of inclusion complexes of 1 : 1 stoichiometry between the drug and cyclodextrins was revealed. The ionization state of sulfasalazine more strongly affects the complex formation than does the structure of cyclodextrins. Compared with a neutral molecule, sulfasalazine anionic species forms with cyclodextrins more stable complexes, which are essentially stabilized by possible surface interactions.
Негізгі сөздер
Авторлар туралы
D. Kuranov
G.A. Krestov Institute of Solution Chemistry
Хат алмасуға жауапты Автор.
Email: kuranov.mitya@mail.ru
Ресей, ul. Akademicheskaya 1, Ivanovo, 153045
E. Chibunova
G.A. Krestov Institute of Solution Chemistry
Email: kuranov.mitya@mail.ru
Ресей, ul. Akademicheskaya 1, Ivanovo, 153045
T. Volkova
G.A. Krestov Institute of Solution Chemistry
Email: kuranov.mitya@mail.ru
Ресей, ul. Akademicheskaya 1, Ivanovo, 153045
I. Terekhova
G.A. Krestov Institute of Solution Chemistry
Email: kuranov.mitya@mail.ru
Ресей, ul. Akademicheskaya 1, Ivanovo, 153045