Complex Formation of Cyclodextrins with Sulfasalazine in Buffer Solutions
- Autores: Kuranov D.1, Chibunova E.1, Volkova T.1, Terekhova I.1
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Afiliações:
- G.A. Krestov Institute of Solution Chemistry
- Edição: Volume 88, Nº 6 (2018)
- Páginas: 1325-1330
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222287
- DOI: https://doi.org/10.1134/S1070363218060439
- ID: 222287
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Resumo
Complex formation of α-, β-, and γ-cyclodextrins with sulfasalazine in biologically relevant buffer solutions (pH 1.2 and 7.4) was studied. Formation of inclusion complexes of 1 : 1 stoichiometry between the drug and cyclodextrins was revealed. The ionization state of sulfasalazine more strongly affects the complex formation than does the structure of cyclodextrins. Compared with a neutral molecule, sulfasalazine anionic species forms with cyclodextrins more stable complexes, which are essentially stabilized by possible surface interactions.
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Sobre autores
D. Kuranov
G.A. Krestov Institute of Solution Chemistry
Autor responsável pela correspondência
Email: kuranov.mitya@mail.ru
Rússia, ul. Akademicheskaya 1, Ivanovo, 153045
E. Chibunova
G.A. Krestov Institute of Solution Chemistry
Email: kuranov.mitya@mail.ru
Rússia, ul. Akademicheskaya 1, Ivanovo, 153045
T. Volkova
G.A. Krestov Institute of Solution Chemistry
Email: kuranov.mitya@mail.ru
Rússia, ul. Akademicheskaya 1, Ivanovo, 153045
I. Terekhova
G.A. Krestov Institute of Solution Chemistry
Email: kuranov.mitya@mail.ru
Rússia, ul. Akademicheskaya 1, Ivanovo, 153045