Complex Formation of Cyclodextrins with Sulfasalazine in Buffer Solutions
- 作者: Kuranov D.1, Chibunova E.1, Volkova T.1, Terekhova I.1
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隶属关系:
- G.A. Krestov Institute of Solution Chemistry
- 期: 卷 88, 编号 6 (2018)
- 页面: 1325-1330
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222287
- DOI: https://doi.org/10.1134/S1070363218060439
- ID: 222287
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详细
Complex formation of α-, β-, and γ-cyclodextrins with sulfasalazine in biologically relevant buffer solutions (pH 1.2 and 7.4) was studied. Formation of inclusion complexes of 1 : 1 stoichiometry between the drug and cyclodextrins was revealed. The ionization state of sulfasalazine more strongly affects the complex formation than does the structure of cyclodextrins. Compared with a neutral molecule, sulfasalazine anionic species forms with cyclodextrins more stable complexes, which are essentially stabilized by possible surface interactions.
作者简介
D. Kuranov
G.A. Krestov Institute of Solution Chemistry
编辑信件的主要联系方式.
Email: kuranov.mitya@mail.ru
俄罗斯联邦, ul. Akademicheskaya 1, Ivanovo, 153045
E. Chibunova
G.A. Krestov Institute of Solution Chemistry
Email: kuranov.mitya@mail.ru
俄罗斯联邦, ul. Akademicheskaya 1, Ivanovo, 153045
T. Volkova
G.A. Krestov Institute of Solution Chemistry
Email: kuranov.mitya@mail.ru
俄罗斯联邦, ul. Akademicheskaya 1, Ivanovo, 153045
I. Terekhova
G.A. Krestov Institute of Solution Chemistry
Email: kuranov.mitya@mail.ru
俄罗斯联邦, ul. Akademicheskaya 1, Ivanovo, 153045