Complex Formation of Cyclodextrins with Sulfasalazine in Buffer Solutions
- Authors: Kuranov D.Y.1, Chibunova E.S.1, Volkova T.V.1, Terekhova I.V.1
-
Affiliations:
- G.A. Krestov Institute of Solution Chemistry
- Issue: Vol 88, No 6 (2018)
- Pages: 1325-1330
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222287
- DOI: https://doi.org/10.1134/S1070363218060439
- ID: 222287
Cite item
Abstract
Complex formation of α-, β-, and γ-cyclodextrins with sulfasalazine in biologically relevant buffer solutions (pH 1.2 and 7.4) was studied. Formation of inclusion complexes of 1 : 1 stoichiometry between the drug and cyclodextrins was revealed. The ionization state of sulfasalazine more strongly affects the complex formation than does the structure of cyclodextrins. Compared with a neutral molecule, sulfasalazine anionic species forms with cyclodextrins more stable complexes, which are essentially stabilized by possible surface interactions.
Keywords
About the authors
D. Yu. Kuranov
G.A. Krestov Institute of Solution Chemistry
Author for correspondence.
Email: kuranov.mitya@mail.ru
Russian Federation, ul. Akademicheskaya 1, Ivanovo, 153045
E. S. Chibunova
G.A. Krestov Institute of Solution Chemistry
Email: kuranov.mitya@mail.ru
Russian Federation, ul. Akademicheskaya 1, Ivanovo, 153045
T. V. Volkova
G.A. Krestov Institute of Solution Chemistry
Email: kuranov.mitya@mail.ru
Russian Federation, ul. Akademicheskaya 1, Ivanovo, 153045
I. V. Terekhova
G.A. Krestov Institute of Solution Chemistry
Email: kuranov.mitya@mail.ru
Russian Federation, ul. Akademicheskaya 1, Ivanovo, 153045