Email this article Synthesis of Biaryl Derivatives of Spirofurochromanone in Water and Their Anticancer Activity
- Authors: Ashok D.1, Madhuri E.V.1,2, Sarasija M.2, Sree Kanth S.3,4, Vijjulatha M.3, Gayatri A.A.5, Sagurthi S.R.5, Krishna N.S.6
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Affiliations:
- Green and Medicinal Chemistry Lab, Department of Chemistry
- Department of Chemistry
- Molecular Modeling and Medicinal Chemistry Group, Department of Chemistry, University, College of Science
- Department of Chemistry, Nizam College
- Department of Genetics, Drug Design and Molecular Medicine Lab
- Analytical Division
- Issue: Vol 89, No 10 (2019)
- Pages: 2129-2135
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223129
- DOI: https://doi.org/10.1134/S1070363219100220
- ID: 223129
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Abstract
Biaryl derivatives of spirofurochromanones have been synthesised from 4-bromophenyl derivatives of spirofurochromanones upon catalysis by Pd/C in water. Structures of the synthesised compounds are derived from IR, NMR and HRMS spectral data. The compounds have been tested for in vitro cytotoxicity supported by docking studies.
About the authors
D. Ashok
Green and Medicinal Chemistry Lab, Department of Chemistry
Author for correspondence.
Email: ashokdou@gmail.com
India, Hyderabad, Telangana, 500007
E. V. L. Madhuri
Green and Medicinal Chemistry Lab, Department of Chemistry; Department of Chemistry
Email: ashokdou@gmail.com
India, Hyderabad, Telangana, 500007; Nizamabad, Telangana, 5033443
M. Sarasija
Department of Chemistry
Email: ashokdou@gmail.com
India, Karimnagar, Telangana, 505001
S. Sree Kanth
Molecular Modeling and Medicinal Chemistry Group, Department of Chemistry, University, College of Science; Department of Chemistry, Nizam College
Email: ashokdou@gmail.com
India, Hyderabad, Telangana, 500007; Hyderabad, Telangana, 500001
M. Vijjulatha
Molecular Modeling and Medicinal Chemistry Group, Department of Chemistry, University, College of Science
Email: ashokdou@gmail.com
India, Hyderabad, Telangana, 500007
Akkiraju Anjini Gayatri
Department of Genetics, Drug Design and Molecular Medicine Lab
Email: ashokdou@gmail.com
India, Hyderabad, Telangana, 500007
Someswar Rao Sagurthi
Department of Genetics, Drug Design and Molecular Medicine Lab
Email: ashokdou@gmail.com
India, Hyderabad, Telangana, 500007
N. Sai Krishna
Analytical Division
Email: ashokdou@gmail.com
India, Hyderabad, Telangana, 500007
