Synthesis and Anti-Inflammatory Activity of Some New Pyrimidinothienocinnoline Derivatives
- Авторы: Fayed A.1,2, Alahmadi Y.3, Yousif M.2, Yousif N.2, Amer A.4, El-Farargy A.4, Ouf N.4, Gad F.2
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Учреждения:
- Respiratory Department (Applied Organic and Biochemistry Division), College of Medical Rehabilitation Sciences
- Photochemistry Department
- Clinical and Hospital Pharmacy Department, College of Pharmacy
- Chemistry Department, Faculty of Science
- Выпуск: Том 89, № 9 (2019)
- Страницы: 1887-1895
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223090
- DOI: https://doi.org/10.1134/S1070363219090251
- ID: 223090
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Аннотация
Synthesis of a new series of pyrimidinothienocinnoline derivatives involves the reaction of 9-aminodibenzo[f, h]pyrimido[4′,5′:4,5]thieno[2,3-c]cinnoline-8-carbonitrile with formamide that gives 8-amino-dibenzo[f, h]-pyrimido[4′,5′:4,5]thieno[2,3-c]cinnoline. Reactions of the latter with morpholine, piperidine, malononitrile, phenylbromide, aromatic aldehydes, and ethyl cyanoacetate have been studied. Some synthesized compounds have been subjected to further transformations. The synthesized pyrimidinothienocinnoline derivatives are tested for their anti-inflammatory activity.
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Об авторах
A. Fayed
Respiratory Department (Applied Organic and Biochemistry Division), College of Medical Rehabilitation Sciences; Photochemistry Department
Email: mahmoud_nabil18@yahoo.com
Саудовская Аравия, Al-Madinah Al-Munawara, 3893; Dokki, Cairo
Y. Alahmadi
Clinical and Hospital Pharmacy Department, College of Pharmacy
Email: mahmoud_nabil18@yahoo.com
Саудовская Аравия, Madina Munawarah, 22624
M. Yousif
Photochemistry Department
Автор, ответственный за переписку.
Email: mahmoud_nabil18@yahoo.com
Египет, Dokki, Cairo
N. Yousif
Photochemistry Department
Email: mahmoud_nabil18@yahoo.com
Египет, Dokki, Cairo
A. Amer
Chemistry Department, Faculty of Science
Email: mahmoud_nabil18@yahoo.com
Египет, Zagazig
A. El-Farargy
Chemistry Department, Faculty of Science
Email: mahmoud_nabil18@yahoo.com
Египет, Zagazig
N. Ouf
Chemistry Department, Faculty of Science
Email: mahmoud_nabil18@yahoo.com
Египет, Zagazig
F. Gad
Photochemistry Department
Email: mahmoud_nabil18@yahoo.com
Египет, Dokki, Cairo
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