Synthesis and Anti-Inflammatory Activity of Some New Pyrimidinothienocinnoline Derivatives
- 作者: Fayed A.1,2, Alahmadi Y.3, Yousif M.2, Yousif N.2, Amer A.4, El-Farargy A.4, Ouf N.4, Gad F.2
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隶属关系:
- Respiratory Department (Applied Organic and Biochemistry Division), College of Medical Rehabilitation Sciences
- Photochemistry Department
- Clinical and Hospital Pharmacy Department, College of Pharmacy
- Chemistry Department, Faculty of Science
- 期: 卷 89, 编号 9 (2019)
- 页面: 1887-1895
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223090
- DOI: https://doi.org/10.1134/S1070363219090251
- ID: 223090
如何引用文章
详细
Synthesis of a new series of pyrimidinothienocinnoline derivatives involves the reaction of 9-aminodibenzo[f, h]pyrimido[4′,5′:4,5]thieno[2,3-c]cinnoline-8-carbonitrile with formamide that gives 8-amino-dibenzo[f, h]-pyrimido[4′,5′:4,5]thieno[2,3-c]cinnoline. Reactions of the latter with morpholine, piperidine, malononitrile, phenylbromide, aromatic aldehydes, and ethyl cyanoacetate have been studied. Some synthesized compounds have been subjected to further transformations. The synthesized pyrimidinothienocinnoline derivatives are tested for their anti-inflammatory activity.
作者简介
A. Fayed
Respiratory Department (Applied Organic and Biochemistry Division), College of Medical Rehabilitation Sciences; Photochemistry Department
Email: mahmoud_nabil18@yahoo.com
沙特阿拉伯, Al-Madinah Al-Munawara, 3893; Dokki, Cairo
Y. Alahmadi
Clinical and Hospital Pharmacy Department, College of Pharmacy
Email: mahmoud_nabil18@yahoo.com
沙特阿拉伯, Madina Munawarah, 22624
M. Yousif
Photochemistry Department
编辑信件的主要联系方式.
Email: mahmoud_nabil18@yahoo.com
埃及, Dokki, Cairo
N. Yousif
Photochemistry Department
Email: mahmoud_nabil18@yahoo.com
埃及, Dokki, Cairo
A. Amer
Chemistry Department, Faculty of Science
Email: mahmoud_nabil18@yahoo.com
埃及, Zagazig
A. El-Farargy
Chemistry Department, Faculty of Science
Email: mahmoud_nabil18@yahoo.com
埃及, Zagazig
N. Ouf
Chemistry Department, Faculty of Science
Email: mahmoud_nabil18@yahoo.com
埃及, Zagazig
F. Gad
Photochemistry Department
Email: mahmoud_nabil18@yahoo.com
埃及, Dokki, Cairo