Synthesis and Anti-Inflammatory Activity of Some New Pyrimidinothienocinnoline Derivatives
- Autores: Fayed A.1,2, Alahmadi Y.3, Yousif M.2, Yousif N.2, Amer A.4, El-Farargy A.4, Ouf N.4, Gad F.2
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Afiliações:
- Respiratory Department (Applied Organic and Biochemistry Division), College of Medical Rehabilitation Sciences
- Photochemistry Department
- Clinical and Hospital Pharmacy Department, College of Pharmacy
- Chemistry Department, Faculty of Science
- Edição: Volume 89, Nº 9 (2019)
- Páginas: 1887-1895
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223090
- DOI: https://doi.org/10.1134/S1070363219090251
- ID: 223090
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Resumo
Synthesis of a new series of pyrimidinothienocinnoline derivatives involves the reaction of 9-aminodibenzo[f, h]pyrimido[4′,5′:4,5]thieno[2,3-c]cinnoline-8-carbonitrile with formamide that gives 8-amino-dibenzo[f, h]-pyrimido[4′,5′:4,5]thieno[2,3-c]cinnoline. Reactions of the latter with morpholine, piperidine, malononitrile, phenylbromide, aromatic aldehydes, and ethyl cyanoacetate have been studied. Some synthesized compounds have been subjected to further transformations. The synthesized pyrimidinothienocinnoline derivatives are tested for their anti-inflammatory activity.
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Sobre autores
A. Fayed
Respiratory Department (Applied Organic and Biochemistry Division), College of Medical Rehabilitation Sciences; Photochemistry Department
Email: mahmoud_nabil18@yahoo.com
Arábia Saudita, Al-Madinah Al-Munawara, 3893; Dokki, Cairo
Y. Alahmadi
Clinical and Hospital Pharmacy Department, College of Pharmacy
Email: mahmoud_nabil18@yahoo.com
Arábia Saudita, Madina Munawarah, 22624
M. Yousif
Photochemistry Department
Autor responsável pela correspondência
Email: mahmoud_nabil18@yahoo.com
Egito, Dokki, Cairo
N. Yousif
Photochemistry Department
Email: mahmoud_nabil18@yahoo.com
Egito, Dokki, Cairo
A. Amer
Chemistry Department, Faculty of Science
Email: mahmoud_nabil18@yahoo.com
Egito, Zagazig
A. El-Farargy
Chemistry Department, Faculty of Science
Email: mahmoud_nabil18@yahoo.com
Egito, Zagazig
N. Ouf
Chemistry Department, Faculty of Science
Email: mahmoud_nabil18@yahoo.com
Egito, Zagazig
F. Gad
Photochemistry Department
Email: mahmoud_nabil18@yahoo.com
Egito, Dokki, Cairo