Synthesis and Anti-Inflammatory Activity of Some New Pyrimidinothienocinnoline Derivatives
- Authors: Fayed A.A.1,2, Alahmadi Y.M.3, Yousif M.N.2, Yousif N.M.2, Amer A.A.4, El-Farargy A.F.4, Ouf N.H.4, Gad F.A.2
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Affiliations:
- Respiratory Department (Applied Organic and Biochemistry Division), College of Medical Rehabilitation Sciences
- Photochemistry Department
- Clinical and Hospital Pharmacy Department, College of Pharmacy
- Chemistry Department, Faculty of Science
- Issue: Vol 89, No 9 (2019)
- Pages: 1887-1895
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223090
- DOI: https://doi.org/10.1134/S1070363219090251
- ID: 223090
Cite item
Abstract
Synthesis of a new series of pyrimidinothienocinnoline derivatives involves the reaction of 9-aminodibenzo[f, h]pyrimido[4′,5′:4,5]thieno[2,3-c]cinnoline-8-carbonitrile with formamide that gives 8-amino-dibenzo[f, h]-pyrimido[4′,5′:4,5]thieno[2,3-c]cinnoline. Reactions of the latter with morpholine, piperidine, malononitrile, phenylbromide, aromatic aldehydes, and ethyl cyanoacetate have been studied. Some synthesized compounds have been subjected to further transformations. The synthesized pyrimidinothienocinnoline derivatives are tested for their anti-inflammatory activity.
About the authors
A. A. Fayed
Respiratory Department (Applied Organic and Biochemistry Division), College of Medical Rehabilitation Sciences; Photochemistry Department
Email: mahmoud_nabil18@yahoo.com
Saudi Arabia, Al-Madinah Al-Munawara, 3893; Dokki, Cairo
Y. M. Alahmadi
Clinical and Hospital Pharmacy Department, College of Pharmacy
Email: mahmoud_nabil18@yahoo.com
Saudi Arabia, Madina Munawarah, 22624
M. N. M. Yousif
Photochemistry Department
Author for correspondence.
Email: mahmoud_nabil18@yahoo.com
Egypt, Dokki, Cairo
N. M. Yousif
Photochemistry Department
Email: mahmoud_nabil18@yahoo.com
Egypt, Dokki, Cairo
A. A. Amer
Chemistry Department, Faculty of Science
Email: mahmoud_nabil18@yahoo.com
Egypt, Zagazig
A. F. El-Farargy
Chemistry Department, Faculty of Science
Email: mahmoud_nabil18@yahoo.com
Egypt, Zagazig
N. H. Ouf
Chemistry Department, Faculty of Science
Email: mahmoud_nabil18@yahoo.com
Egypt, Zagazig
F. A. Gad
Photochemistry Department
Email: mahmoud_nabil18@yahoo.com
Egypt, Dokki, Cairo
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